devACT® Clinical Management Panel

Next Generation Sequencing panel focused on genes that inform actionable clinical management of patients with Developmental Delay, Intellectual Disability, and Autism Spectrum Disorders

Courtagen’s devACT® Clinical Management Panel provides the rapid analysis of genes that can inform meaningful treatment options while potentially avoiding both costly and invasive alternative diagnostic procedures.

Many patients presenting with developmental and behavioral phenotypes, including developmental delay, intellectual disability, and autism spectrum disorders, experience a diagnostic work-up that consists of many tests over an extended time period. Results from Courtagen’s Clinical Management Panel can be obtained from a single saliva sample. This test enables health care providers to efficiently test patients, presenting with clinical features of intellectual disability, for treatable genetic conditions. This panel promotes treatability in the work up of patients with the potential to improve health outcomes.


Effectively Screen for Many Conditions

devACT® is an actionable panel that includes treatable cause of ID/DD/ASD, as well as disorders that are currently queried for by extensive biochemical testing (Congenital Disorders of Glycosylation (CDG), Very Long Chain Fatty Acids (VLCFA), oligosaccharides/mucopolysaccharidoses (MPS), Urine Organic Acids (UOA), Plasma Amino Acids (PAA), neurotransmitters, pterins, folate metabolites, cerebrospinal fluid (CSF) glucose, magnetic resonance spectroscopy (MRS) for creatine, purines and pyrimidines, etc.). The devACT® test is designed to be indispensable as it screens for many treatable conditions far more effectively than lengthy diagnostic work ups that are substantially less complete. 

Potential Treatments

  • Biotin Therapy, Creatine Therapy, Folinic Acid, CoQ10, L-carnitine, Riboflavin, Vitamin B6, Vitamin B12, Vitamin K
  • Ketogenic Diet and other specialized diets

Potential Avoidance of Procedures

  • Anesthesia
  • Biopsy
  • Lumbar Puncture
  • MRI
  • Multi test work-up over extended period

Product Information Sheet

devACT® Clinical Management Panel for Neurodevelopmental Disorders

devACT® Panel Gene List

Methylation SNP Analysis for devSEEK & devACT Panels

Courtagen's Unmatched Customer Support

Turn Around Time: 4-6 weeks. Results are delivered in weeks, not months.

Saliva Sample: DNA for sequencing is reliably extracted from a single saliva sample. No blood draw or muscle biopsy required. (Whole blood and tissue are accepted, as requested.)

Insurance Assistance: Courtagen works with patients, physicians, and insurance carriers to pre-approve each test. Courtagen will bill the insurance company, and is willing to handle an appeal process as needed.

Courtagen Care Financial Assistance Program: Provides financial assistance to patients based on demonstrated financial need. A qualified applicant may be asked to contribute between $0 and a maximum cost sharing of $200 depending on determination of financial need.

Online Portal: A secure physician online portal is available for ordering genetic tests and accessing patient reports when completed.

Genetic Counselors: Available to address physician’s questions regarding Courtagen test results. Contact us at

Clinical Experience: Courtagen’s Medical Director, Laboratory Director, and variant science team have over 25 years of experience in the treatment and genetic interpretation of neurological and metabolic disorders.

Reports: Utilizing Courtagen’s customized Ziphyr® informatics pipeline and thorough clinical evaluation, each report is provided in a concise format with interpretation and recommendations for consideration.

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