nucSEEK®  Comprehensive Sequence Analysis Of The Nuclear Mitochondrial Exome


Mitochondrial disorders are very diverse conditions and can affect one or multiple systems of the body. Mitochondrial dysfunction depletes cells of energy causing cell damage and even cell death.

There are over 1,000 proteins encoded in the nuclear genome that are imported into the mitochondria. Courtagen’s nucSEEK® test uses Next Generation Sequencing to detect variants in these nuclear genes. The analysis and interpretation of a patient’s nuclear mitochondrial exome is valuable for obtaining a definitive diagnosis, estimating prognosis, guiding treatment choices, and determining recurrence risks.


Del/Dup Additional Analysis (181 genes): Additional analysis of exon-sized (and larger) deletion and duplication variants in 182 genes is available as an add-on for both the nucSEEK Focus and nucSEEK Comprehensive panels.

Product Information Sheets:


nucSEEK® Comprehensive Sequence Analysis Of The Nuclear Mitochondrial Exome



Courtagen's Unmatched Customer Support


Turn Around Time: 4-6 weeks. Results are delivered in weeks, not months.

Saliva Sample: DNA for sequencing is reliably extracted from a single saliva sample. No blood draw or muscle biopsy required. (Whole blood and tissue are accepted, as requested.)

Insurance Assistance: Courtagen works with patients, physicians, and insurance carriers to pre-approve each test. Courtagen will bill the insurance company, and is willing to handle an appeal process as needed.

Courtagen Care Financial Assistance Program: Provides financial assistance to patients based on demonstrated financial need. A qualified applicant may be asked to contribute between $0 and a maximum cost sharing of $200 depending on determination of financial need.

Online Portal: A secure physician online portal is available for ordering genetic tests and accessing patient reports when completed.

Genetic Counselors: Available to address physician’s questions regarding Courtagen test results. Contact us at clinical@courtagen.com.

Clinical Experience:
Courtagen’s Medical Director, Laboratory Director, and variant science team have over 25 years of experience in the treatment and genetic interpretation of neurological and metabolic disorders.

Reports: Utilizing Courtagen’s customized Ziphyr® informatics pipeline and thorough clinical evaluation, each report is provided in a concise format with interpretation and recommendations for consideration.

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